Tablet Dissolution and Content Uniformity Testing for HPLC Assay

Ultrasonic energy applied in a process called sonication, is widely used to dissolve the pharmaceutical tablets for HPLC analysis procedures such as content uniformity testing. Sonic kits can also be used to mix and disperse samples, and for solvent degassing. Sonic kits are ideal for USP methods that specify the use of ultrasonic cleaning for sample preparation. More detailed methods for USP recommend using an ultrasonic bath to extract the pharmaceutical active substance (API) from tablet formulations. When samples test preparation HPLC pharmaceutical care must be taken to prevent chemical degradation due to excessive heat APIs. It is therefore important that sonication is done quickly process itself generates heat. One way to achieve this goal is to use a pharmaceutical kit sonic tablet components allow tablet dissolution up to 16 times faster than conventional systems. Fast dissolving tablet and excellent recovery of pharmaceutical active ingredient is still argued that u
ltrasound bath design eliminates dead spots and maximize ultrasonic sonication power, operating at 320 and 415 watts respectively for the two models. Combined characteristics of these units to minimize heat gain, increase power ultrasonic dispersion, and to minimize transducer mass burn marks and etching.These ball rack kits include specially designed film sonication for trial balloons position just right in a bath depth ultrasound to allow the maximum acoustic energy to reach the balloon. Bath consisting of water and an amplifier optional additive to enhance sonic cavitation.